発表文献・記事集 / Scientific Articles

2017

Gene Therapy

  • Genomic Signature of the Natural Oncolytic Herpes Simplex Virus HF10 and Its Therapeutic Role in Preclinical and Clinical Trials.
    Eissa I, Naoe Y, Bustos-Villalobos I, Ichinose T, Zhiwen W, Kasuya H, Morimoto T, Kodera Y, Tanaka M, Mukoyama N, Miyajima N, Hasegawa H, Sumigama S, Aleksic B. Frontiers in oncology. 2017 Jul 14; 7:Article 149. doi: 10.3389/fonc.2017.00149
  • Curative effect of HF10 on liver and peritoneal metastasis mediated by host antitumor immunity.
    Hotta Y, Kasuya H, Bustos I, Naoe Y, Ichinose T, Tanaka M, Kodera Y. Oncolytic Virother. 2017 Mar 13; 6:31-38. doi: 10.2147/OV.S127179. eCollection 2017.

2016

PCR

  • 鼻科基礎研究ハンズオンセミナーの取り組み(第2報)
    Kanda A, Noyama Y, Yun Y, Kashima A, Takeno S, Okano M, Izumi K, Ohba T, Kobayashi Y, Tomoda K, Fujieda S, Hirakawa K, Kawauchi H., 日本鼻科学会会誌(Web) . 2016 Jul 23; 55(2):176-185.

Enzyme

  • Identification of a mismatch-specific endonuclease in hyperthermophilic Archaea.
    Ishino S, Nishi Y, Oda S, Yamagami T, Ishino Y, Uemori T, Sagara T, Takatsu N, Shirai T., Nucleic acids research. 2016 Mar 21; 44(7):2977-2986.

Protein Engineering

  • Sequential formation of two branched intermediates during protein splicing of class three inteins.
    Tori K, Perler F., Extremophiles : Microbial Life Under Extreme Conditions. 2016 Oct 4; 21(1):41-49.

Gene Therapy

  • Efficient tumor regression by adoptively transferred CEA-specific CAR-T cells associated with symptoms of mild cytokine release syndrome.
    Wang L, Ma N, Okamoto S, Amaishi Y, Sato E, Seo N, Mineno J, Takesako K, Kato T, Shiku H., OncoImmunology. 2016 Sep 1; 5(9):e1211218.
  • A Functionally Superior Second-Generation Vector Expressing an Aurora Kinase-A-Specific T-Cell Receptor for Anti-Leukaemia Adoptive Immunotherapy.
    Casey Nicholas Paul, Fujiwara Hiroshi, Tanimoto Kazushi, Yasukawa Masaki, Okamoto Sachiko, Mineno Junichi, Kuzushima Kiyotaka, Shiku Hiroshi., PLOS ONE. 2016 Jun 7; 11(6):e0156896.
  • Development of engineered T cells expressing a chimeric CD16-CD3ζ receptor to improve the clinical efficacy of mogamulizumab therapy against adult T cell leukemia.
    Tanaka H, Fujiwara H, Casey N, Yasukawa M, Ochi F, Tanimoto K, Okamoto S, Mineno J, Kuzushima K, Shiku H Barrett J., Clinical cancer research. 2016 Sep 1; 22(17):4405-4416.
  • CD4(+) and CD8(+) TCRβ repertoires possess different potentials to generate extraordinarily high-avidity T cells.
    Nakatsugawa M, Rahman M, Yamashita Y, Ochi T, Wnuk P, Tanaka S, Chamoto K, Kagoya Y, Saso K, Guo T, Hirano N, Wnuk P, Anczurowski M, Butler Marcus O., Scientific reports. 2016 Mar 31;6:23821.

AgriBio

  • Protective effect of agaro-oligosaccharides on gut dysbiosis and colon tumorigenesis in high-fat diet-fed mice.
    Higashimura Y, Naito Y, Takagi T, Uchiyama K, Mizushima K, Ushiroda C, Yoshikawa T, Ohnogi H, Kudo Y, Yasui M, Inui S, Hisada T, Honda A, Matsuzaki Y., American journal of physiology. Gastrointestinal and liver physiology. 2016 Mar 15; 310(6):G367-G375.

2015

Real-Time RT-PCR

  • Detection of legionella species in environmental water by the quantitative pcr method in combination with ethidium monoazide treatment.
    Inoue H, Takama T, Agata K, Yoshizaki M, Biocontrol Science. 2015 Mar 30;20(1):71-74.

Stem Cells

  • Human induced hepatic lineage-oriented stem cells: autonomous specification of human iPS cells toward hepatocyte-like cells without any exogenous differentiation factors.
    Ishikawa T, Kobayashi M, Yanagi S, Kato C, Takashima R, Kobayashi E, Hagiwara K, Ochiya T., PloS one. 2015 Apr 13;10(4):e0123193.

Gene Therapy

  • Direct tumor recognition by a human CD4(+) T-cell subset potently mediates tumor growth inhibition and orchestrates anti-tumor immune responses.
    Matsuzaki J, Tsuji T, Odunsi K, Old Lloyd J, Gnjatic S, Luescher I, Shiku H, Mineno J, Okamoto S, Shrikant P., Scientific reports. 2015 Oct 8;5:14896.
  • Donor lymphocytes expressing the herpes simplex virus thymidine kinase suicide gene: detailed immunological function following add-back after haplo-identical transplantation.
    Hashimoto H, Ueda R, Kitano S, Yamagata S, Ito A, Fuji S, Yamashita T, Fukuda T, Miyagi Maeshima A, Tada K, Tomura D, Nukaya I, Mineno J, Mori S, Takaue Y, Heike Y., Cytotherapy. 2015 Oct 6;17(12):1820-1830.
  • Phase I clinical trial of autologous NK cell therapy using novel expansion method in patients with advanced digestive cancer.
    Sakamoto N, Ishikawa T, Kokura S, Okayama T, Oka K, Naito Y, Itoh Y, Yoshikawa T, Ideno M, Sakai F, Kato A, Tanabe M, Enoki T, Mineno J., Journal of translational medicine. 2015 Aug 25;13:277.
  • Differentiation kinetics of blood monocytes and dendritic cells in macaques: Insights to understanding human myeloid cell development.
    Sugimoto C, Hasegawa A, Saito Y, Fukuyo Y, B. Chiu K, Cai Y, Kuroda M, Breed M, Lackner A, Mori K, Roy C, Didier E, Kim W., Journal of immunology. 2015 Jul 15;195(4):1774-1781.
  • Antileukemia multifunctionality of CD4(+) T cells genetically engineered by HLA class I-restricted and WT1-specific T-cell receptor gene transfer.
    Fujiwara H, Ochi T, Ochi F, Miyazaki Y, Asai H, Yasukawa M, Narita M Okamoto S, Mineno J, Kuzushima K, Shiku H., Leukemia. 2015 Jun 24;29(12):2393-2401.
  • Erratum to:
    Infusion of donor lymphocytes expressing the herpes simplex virus thymidine kinase suicide gene for recurrent hematologic malignancies after allogeneic hematopoietic stem cell transplantation.
    Hashimoto H,; Ueda R, Kitano S, Tada K, Ito A, Fuji S, Kim S, Yamashita T, Fukuda T, Tomura D, Nukaya I, Mineno J, Mori S, Takaue Y, Heike Y., International journal of hematology. 2015 Sep 11;102(4):506.
  • Infusion of donor lymphocytes expressing the herpes simplex virus thymidine kinase suicide gene for recurrent hematologic malignancies after allogeneic hematopoietic stem cell transplantation.
    Hashimoto H, Ueda R, Kitano S, Tada K, Ito A, Fuji S, Yamashita T, Fukuda T, Tomura D, Nukaya I, Mineno J, Mori S, Takaue Y, Heike Y., International Journal of Hematology. 2015 May 7;102(1):101-110.
  • Optimization of T-cell Reactivity by Exploiting TCR Chain Centricity for the Purpose of Safe and Effective Antitumor TCR Gene Therapy.
    Ochi T, Nakatsugawa M, Chamoto K, Yamashita Y, Tanaka S, Guo T, Hirano N, Fujiwara H, Yasukawa M, Butler M., Cancer immunology research. 2015 May 5;3(9):1070-1081.
  • Outcomes in Two Japanese Adenosine Deaminase-Deficiency Patients Treated by Stem Cell Gene Therapy with No Cytoreductive Conditioning.
    Otsu M, Yamada M, Hatano N, Toita N, Takezaki S, Okura Y, Kobayashi R, Matsumoto Y, Kawamura N, Sakiyama Y, Ariga T, Nakajima S, Kida M, Maeyama Y, Tatsuzawa O, Onodera M, Tsuchida F, Kato, S, Kitagawa M, Mineno J, Hershfield M, Bali P, Candotti F., Journal of Clinical Immunology. 2015 Apr 15;35(4):383-398.
  • Adoptive Transfer of MAGE-A4 T-cell Receptor Gene-Transduced Lymphocytes in Patients with Recurrent Esophageal Cancer.
    Kageyama S, Ikeda H, Miyahara Y, Imai N, Sugino S, Shiku H, Ishihara M, Saito K, Ueda S, Ishikawa T, Kokura S, Naota H, Ohishi K, Shiraishi T, Inoue N, Tanabe M, Kidokoro T, Yoshioka H, Tomura D, Nukaya I, Mineno J, Takesako K., Clinical cancer research. 2015 Apr 8;21(10):2268-2277.
  • がん免疫細胞療法開発への企業側の取り組み
    峰野純一 月刊腫瘍内科. 2015 Mar 28;15(3):315-319.
  • Specific roles of each TCR hemichain in generating functional chain-centric TCR.
    Nakatsugawa M, Yamashita Y, Ochi T, Chamoto K, Tanaka S, Guo T, Hirano N, Butler M., Journal of immunology. 2015 Feb 20;194(7):3487-3500.

AgriBio

  • ガゴメ昆布由来フコイダンの健常成人の免疫機能への有効性ならびに安全性の評価
    ( Immune Efficacy and Safety of Fucoidan Extracted from Gagome Kombu (Kjellmaniella crassifolia) in Healthy Japanese Subjects)
    大野木宏, 東村泰希, 吉川敏一, 内藤裕二, 宇野賀津子., 日本補完代替医療学会誌. 2015 Dec 25;12(2):87-93.

2014

RetroNectin

  • Phase I Clinical Trial of Fibronectin CH296-Stimulated T Cell Therapy in Patients with Advanced Cancer.
    Ishikawa T, Kokura S, Enoki T, Sakamoto N, Okayama T, Ideno M, Mineno J, Uno K, Yoshida N, Kamada K, Katada K, Uchiyama K, Handa O, Takagi T, Konishi H, Yagi N, Naito Y, Itoh Y, Yoshikawa T, PLoS One. 2014 Jan 31;9(1):e83786.
  • An Efficient Large-Scale Retroviral Transduction Method Involving Preloading the Vector into a RetroNectin-Coated Bag with Low-Temperature Shaking.
    Dodo K, Chono H, Saito N, Tanaka Y, Tahara K, Nukaya I, Mineno J., PLoS One. 2014 Jan 15;9(1):e86275.

Gene Therapy

  • Identification and characterization of nuclear and nucleolar localization signals in the adeno-associated virus serotype 2 assembly-activating protein.
    Earley Lauriel F, Kawano Y, Adachi K, Sun X, Dai M, Nakai H., Journal of virology. 2014 Dec 31;89(6):3038-3048.
  • The Tol2 transposon system mediates the genetic engineering of T-cells with CD19-specific chimeric antigen receptors for B-cell malignancies.
    Tsukahara T, Uchibori R, Iwase N, Urabe M, Mizukami H, Kume A, Kawakami K, Iwasaki M, Yamamoto C, Ohmine K, Teruya T, Ido H, Saga Y, Nakamura M, Brentjens R, Ozawa K., Gene therapy. 2014 Nov 27;22(2):209-215.
  • キメラ型CD16‐CD3ζ受容体を発現させた遺伝子改変ヒトα/β‐T細胞の抗腫瘍抗体療法への応用
    (Gene-modified human α/β-T cells expressing a chimeric CD16-CD3ζ receptor as adoptively transferable effector cells for anticancer monoclonal antibody therapy)
    OCHI F, ISHII E, FUJIWARA H, TANIMOTO K, MIYAZAKI Y, ASAI H, YASUKAWA M, OKAMOTO S, MINENO J, KUZUSHIMA K, SHIKU H, BARRETT J., 日本小児血液・がん学会雑誌. 2014 Oct 31;51(4):227.
  • 日本発の創薬革命-革新的創薬・育薬に向けたアカデミア・行政・企業の果たすべき役割-再生医療製品の開発 再生医療製品の開発-企業の立場から-
    峰野純一., 臨床医薬 2014 Sep 30;30(9):727-734.
  • Combination therapy of oncolytic herpes simplex virus HF10 and bevacizumab against experimental model of human breast carcinoma xenograft.
    Tan G, Kasuya H, Sahin T, Yamamura K, Wu Z, Koide Y, Hotta Y, Shikano T, Yamada S, Kanzaki A, Fujii T, Sugimoto H, Nomoto S, Nishikawa Y, Tsurumaru N, Kuwahara T, Fukuda S, Ichinose T, Takeda S, Nakao A, Kodera Y, Tanaka M, Kikumori T., International Journal of Cancer. 2014 Sep 27;7:1718-1730.
  • Systemic CD8+ T cell-mediated tumoricidal effects by intratumoral treatment of oncolytic herpes simplex virus with the agonistic monoclonal antibody for murine glucocorticoid-induced tumor necrosis factor receptor.
    Ishihara M, Seo N, Muraoka D, Ikeda H, Shiku H, Mitsui J, Tanaka M, Mineno J., PloS one. 2014 Aug 8;9(8):e104669.
  • CD4+ T cells modified by the endoribonuclease MazF are safe and can persist in SHIV-infected rhesus macaques.
    Saito N, Chono H, Mineno J, Shibata H, Ageyama N, Yasutomi Y., Molecular Therapy - Nucleic Acids. 2014 Jun 10;3(6):e618.
  • Stimulation through very late antigen-4 and -5 improves the multifunctionality and memory formation of CD8+ T cells.
    European Journal of Immunology. 2014 May 11;44(6):1747-1758.
  • Combination treatment of human pancreatic cancer xenograft models with the epidermal growth factor receptor tyrosine kinase inhibitor erlotinib and oncolytic herpes simplex virus hf10.
    Yamamura K, Kasuya H, Sahin T, Tan G, Hotta Y, Tsurumaru N, Fukuda S, Kanda M, Kobayashi D, Tanaka C, Yamada S, Nakayama G, Fujii T, Sugimoto H, Koike M, Nomoto S, Fujiwara M, Kodera Y, Tanaka M., Annals of Surgical Oncology. 2014 Feb 20;21(2):691-698.
  • Drawing a high-resolution functional map of adeno-associated virus capsid by massively parallel sequencing.
    Adachi K, Enoki T, Kawano Y, Veraz M, Nakai H., Nat. Commun. 2014 Jan 17;5:3075.

AgriBio

  • Preventive effect of agaro-oligosaccharides on non-steroidal anti-inflammatory drug-induced small intestinal injury in mice.
    Higashimura Y, Naito Y, Takagi T, Tanimura Y, Mizushima K, Harusato A, Fukui A, Yoriki H, Handa O, Ohnogi H, Yoshikawa T., Journal of Gastroenterology and Hepatology . 2014 Feb 1;29(2):310-317.

2013

Gene Therapy

  • Development of a novel redirected T cell-based adoptive immunotherapy targeting human telomerase reverse transcriptase for adult T-cell leukemia.
    Miyazaki Y, Fujiwara H, Asai H, Ochi F, Ochi T, Azuma T, Ishida T, Okamoto S, Mineno J, Kuzushima K, Shiku H, Yasukawa M., Blood. 2013 121(24),4894-4901.
  • Adoptive transfer of genetically modified Wilms' tumor 1-specific T cells in a novel malignant skull base meningioma model.
    Iwami K, Natsume A, Ohno M, Ikeda H, Mineno J, Nukaya I, Okamoto S, Fujiwara H, Yasukawa M, Shiku H, Wakabayashi T., Neuro Oncol. 2013 Jun;15(6):747-758.
  • Sustained inhibition of HIV-1 replication by conditional expression of the E. coli-derived endoribonuclease MazF in CD4+ T cells.
    Okamoto M, Chono H, Kawano Y, Saito N, Tsuda H, Inoue K, Kato I, Mineno J, Baba M., Hum Gene Ther Methods. 2013 Apr;24(2):94-103.
  • Co-introduced functional CCR2 potentiates in vivo anti-lung cancer functionality mediated by T cells double gene-modified to express WT1-specific T-cell receptor.
    Asai H, Fujiwara H, An J, Ochi T, Miyazaki Y, Nagai K, Okamoto S, Mineno J, Kuzushima K, Shiku H, Inoue H, Yasukawa M., PLoS One. 2013;8(2):e56820.
  • Manipulation of human early T lymphopoiesis by coculture on human bone marrow stromal cells: potential utility for adoptive immunotherapy.
    Liu B, Ohishi K, Orito Y, Nakamori Y, Nishikawa H, Ino K, Suzuki K, Matsumoto T, Masuya M, Hamada H, Mineno J, Ono R, Nosaka T, Shiku H, Katayama N., Exp Hematol. 2013 Apr;41(4):367-76.e1.

2012

Gene Therapy

  • A Promising Vector for TCR Gene Therapy: Differential Effect of siRNA, 2A Peptide, and Disulfide Bond on the Introduced TCR Expression.
    Okamoto S, Amaishi Y, Goto Y, Ikeda H, Fujiwara H, Kuzushima K, Yasukawa M, Shiku H, Mineno J., Mol Ther Nucleic Acids. 2012 Dec 18;1:e63.
  • HLA-restricted presentation of WT1 tumor antigen in B-lymphoblastoid cell lines established using a maxi-EBV system.
    Kanda T, Ochi T, Fujiwara H, Yasukawa M, Okamoto S, Mineno J, Kuzushima K, Tsurumi T., Cancer Gene Ther. (2012) 8:566-571,
  • Aurora kinase A-specific T-cell receptor gene transfer redirects T lymphocytes to display effective anti-leukemia reactivity.
    Nagai K, Ochi T, Fujiwara H, An J, Shirakata T, Mineno J, Kuzushima K, Shiku H, Melenhorst JJ, Gostick E, Price DA, Ishii E, Yasukawa M., Blood. (2012) 119:368-376,
  • T-cell receptor gene therapy targeting melanoma-associated antigen-A4 inhibits human tumor growth in non-obese diabetic/SCID/γc(null) mice. Shirakura Y, Mizuno Y, Wang L, Imai N, Amaike C, Sato E, Ito M, Nukaya I, Mineno J, Takesako K, Ikeda H, Shiku H., Cancer Sci. (2012) 103:17-25
  • siRNA-mediated silencing of PD-1 ligands enhances tumor-specific human T-cell effector functions.
    Iwamura K, Kato T, Miyahara Y, Naota H, Mineno J, Ikeda H, Shiku H., Gene Therapy 2012,19(10), 959-966.

AgriBio

  • Anti-tumor-Promoting Activities of Agaro-Oligosaccharides on Two-Stage Mouse Skin Carcinogenesis.
    Enoki T, Tominaga T, Takashima F, Ohnogi H, Sagawa H, Kato I. Biol. Pharm. Bull. (2012), 35(7), 1145-1149.
  • Angelica keiskei Extract Improves Insulin Resistance and Hypertriglyceridemia in Rats Fed a High-Fructose Drink.
    Hiromu Ohnogi [Reprint Author], Shoko Hayami, Yoko Kudo, Suzu Deguchi, Shigetoshi Mizutani, Tatsuji Enoki, Yuko Tanimura, Wataru Aoi, Yuji Naito, Ikunoshin Kato, Toshikazu Yoshikawa, Bioscience Biotechnology and Biochemistry May 2012, Vol.76 (5) p928-932.
  • Six New Chalcones from Angelica keiskei Inducing Adiponectin Production in 3T3-L1 Adipocytes.
    Hiromu Ohnogi [Reprint Author]; Yoko Kudo, Kenichi Tahara, Katsumi Sugiyama, Tatsuji Enoki, Shoko Hayami, Hiroaki Sagawa, Yuko Tanimura, Wataru Aoi, Yuji Naito, Ikunoshin Kato, Toshikazu Yoshikawa, Bioscience Biotechnology and Biochemistry May 2012, Vol.76 (5) p961-966.

2011

Real-Time RT-PCR (Japanese)

  • Detection and Quantitation of Norovirus Genome Using Real-Time RT-PCR.
    Masashi Fujii, Junko Yamamoto, Hiroyuki Mukai, Masahiro Fujita, Hiroyuki Tsukagoshi, Masakazu Yoshizumi, Mika Saito, Kunihisa Kozawa, and Hirokazu Kimura., Japanese Journal of Food Microbiology June 2011, Vol.28 (2) p139-142.

Plants

  • Alteration of fruit characteristics in transgenic tomatoes with modified expression of a xyloglucan endotransglucosylase/hydrolase gene.
    Toshiharu Ohba, Shuichi Takahashi, Kiyozo Asada., Plant Biotechnology March 2011, Vol.28 (1) p25-32.

RetroNectin

  • Optimization of lentiviral vector transduction into peripheral blood mononuclear cells in combination with the fibronectin fragment CH-296 stimulation.
    Chono H, Goto Y, Tanaka S, Tosaka Y, Nukaya I, Mineno J., The Journal of Biochemistry March 2011, Vol.149 (3) p285-292.

Gene Therapy

  • Novel adoptive T-cell immunotherapy using a WT1-specific TCR vector encoding silencers for endogenous TCRs shows marked anti-leukemia reactivity and safety.
    Ochi T, Fujiwara H, Okamoto S, An J, Nagai K, Shirakata T, Mineno J, Kuzushima K, Shiku H, Yasukawa M., Blood. (2011) 118:1495-1503.
  • Gemcitabine enhances Wilms' tumor gene WT1 expression and sensitizes human pancreatic cancer cells with WT1-specific T-cell-mediated antitumor immune response.
    Takahara A, Koido S, Ito M, Nagasaki E, Sagawa Y, Iwamoto T, Komita H, Ochi T, Fujiwara H, Yasukawa M, Mineno J, Shiku H, Nishida S, Sugiyama H, Tajiri H, Homma S., Cancer Immunol Immunother. (2011) 60:1289-1297.
  • Activation of T-cell receptor signaling in peripheral T-cell lymphoma cells plays an important role in the development of lymphoma-associated hemophagocytosis.
    An J, Fujiwara H, Suemori K, Niiya T, Azuma T, Tanimoto K, Ochi T, Akatsuka Y, Mineno J, Ozawa H, Ishikawa F, Kuzushima K, Yasukawa M, Int J Hematol. (2011) 93: 176-185.
  • In Vivo Safety and Persistence of Endoribonuclease Gene-Transduced CD4+ T Cells in Cynomolgus Macaques for HIV-1 Gene Therapy Model.
    Chono H, Saito N, Tsuda H, Shibata H, Ageyama N, et al., PLoS ONE August 2011, Vol.6 (8): e23585. doi:10.1371/journal.pone.0023585
  • Acquisition of HIV-1 Resistance in T Lymphocytes Using an ACA-Specific E. coli mRNA Interferase.
    Chono H, Matsumoto K, Tsuda H, Saito N, Lee K, Kim S, Shibata H, Ageyama N., Terao K, Yasutomi Y, Mineno J, Kim S, Inouye M, Kato I., Human Gene Therapy January 2011, Vol.22 (1) p35-43.

2010

AgriBio

  • Oligosaccharides form agar inhibit pro-inflammatory mediators release by Inducing heme oxygenase 1.
    Enoki T, Okuda S, Kudo Y, Takashima F, Sagawa H, Kato I., Biosci. Biotechnol. Biochem Vol.74 p766-770.
  • Antioxidant activity of pigments from sake lees fermented with mushroom.
    Kamon T, Kajibe T, Takashima C, Matsui T, Otsuki I, Taguchi M, Tabata M., mushroom science and biotechnology Vol.18 p107-110.
  • Anti-diabetic Activities of Chalcones Derived from Ashitaba.
    Enoki T, Sagawa H, Kobayashi E, Onogi H. Journal of the Japanese Society for Food Science and Technology Vol.57 p456-463.

2009

Gene Therapy

  • Improved Expression and Reactivity of Transduced Tumor-Specific TCRs in Human Lymphocytes by Specific Silencing of Endogenous TCR
    Okamoto S, Mineno J, Ikeda H, Fujiwara H, Yasukawa M, Shiku H, and Kato I., Cancer Research Vol.69 p9003-9011.
  • Rapid αβ TCR-mediated responses in γδ T cells transduced with cancer-specific TCR genes.
    Hiasa A, Nishikawa H, Hirayama M, Kitano S, Okamoto S, Chono H, Yu SS, Mineno J, Tanaka Y, Minato N, Kato I, Shiku H., Gene therapy Vol.16 (5) p620-628.
    ISSN : 0969-7128_(print) 1476-5462_(electronic)

Glycobiology

  • High levels of E4-PHA-reactive oligosaccharides: potential as marker for cells with characteristics of hepatic progenitor cells.
    Sasaki N, Moriwaki K, Uozumi N, Noda K, Taniguchi N, Kameyama A, Narimatsu H, Takeishi S, Yamada M, Koyama N, Miyoshi E., Glycoconj J Vol.26, p1213-1223.

Plants

  • ARTRA:a new database of the Arabidopsis transcriptome and gene-specific sequences for microarray probes and RNAi triggers.
    Ohba Toshiharu, et al., Plant Biotechnology Vol.26, p161-165.

2008

Gene Therapy

  • Long-term phenotypic, functional and genetic stability of cancer-specific T-cell receptor (TCR) alphabeta genes transduced to CD8+ T cells.
    Hiasa A, Hirayama M, Nishikawa H, Kitano S, Nukaya I, Yu SS, Mineno J, Kato I, Shiku H., Gene therapy Vol.15 (9) p695-699.
    ISSN : 0969-7128_(print) 1476-5462_(electronic)

RetroNectin

  • In vivo persistence of genetically modified T cells generated ex vivo using the fibronectin CH296 stimulation method.
    Yu SS, Nukaya I, Enoki T, Chatani E, Kato A, Goto Y, Dan K, Sasaki M, Tomita K, Tanabe M, Chono H, Mineno J, Kato I., Cancer gene therapy Vol.15 (8) p508-516.
    ISSN : 0929-1903_(print) 1476-5500_(electronic)

Retroviral gene expression

  • Transient gene expression mediated by integrase-defective retroviral vectors.
    Yu SS, Dan K, Chono H, Chatani E, Mineno J, Kato I., Biochem. Biophys. Res. Commun. Vol.368 (4) p942-947.
    ISSN : 0006-291X_(print) 1090-2104_(electronic)

Glycobiology

  • Identification of an inducible factor secreted by pancreatic cancer cell lines that stimulates the production of fucosylated haptoglobin in hepatoma cells.
    Narisada M, Kawamoto S, Kuwamoto K, Moriwaki K, Nakagawa T, Matsumoto H, Asahi M, Koyama N, Miyoshi E., Biochem. Biophys. Res. Commun. Vol.377 (3) p792-796.
    ISSN : 0006-291X_(print) 1090-2104_(electronic)

Plants

  • Factors influencing efficiency of transient gene expression in the red macrophyte Porphyra yezoensis.
    Satoru Fukuda, Koji Mikami, Toshiki Uji, Eun-Jeong Park, Toshiharu Ohba, Kiyozo Asada, Yukihiro Kitade, Hirotoshi Endo, Ikunoshin Kato, Naotsune Saga , Plant Science, Vol.174 (3) p329-339.
    ISSN : 0168-9452 (print)

ICAN method

  • SNP typing of aldehyde dehydrogenase2 gene with Cycleave ICAN.
    Mukai Hiroyuki, et al., Molecular and Cellular Probes Vol.22 (5-6) p333-337.
    ISSN : 0890-8508

2007

Low-temperature protein expression system

  • Proteomic studies of an Antarctic cold-adapted bacterium, Shewanella livingstonensis Ac10, for global identification of cold-inducible proteins.
    Kawamoto J, Kurihara T, Kitagawa M, Kato I, Esaki N., Extremophiles Vol.11 (6) p819-826. (United States)
    ISSN : 1431-0651_(print) 1433-4909_(electronic)
  • Construction of a low-temperature protein expression system using a cold-adapted bacterium, Shewanella sp. strain Ac10, as the host.
    Ryoma Miyake, Jun Kawamoto, Yun-lin Wei, Masanari Kitagawa, Ikunoshin Kato, Tatsuo Kurihara, Nobuyoshi Esaki, Appl Environ Microbiol. Vol.73 (15) p4849-4856 (United States)
    ISSN : 0099-2240_(print) 1098-5336_(electronic)

Reductive evolution

  • Reduced genome of the thioautotrophic intracellular symbiont in a deep-sea clam, Calyptogena okutanii.
    Kuwahara H, Yoshida T, Takaki Y, Shimamura S, Nishi S, Harada M, Matsuyama K, Takishita K, Kawato M, Uematsu K, Fujiwara Y, Sato T, Kato C, Kitagawa M, Kato I, Maruyama T., Current biology Vol.17 (10) p881-886 (England)
    ISSN : 0960-9822_(print) 1879-0445_(electronic)

ICAN method

  • Investigation of the Molecular Mechanism of ICAN, a Novel Gene Amplification Method.
    Uemori Takashi, et al., Journal of biochemistry Vol.142 (2) p283-9 2(Japan)
    ISSN : 0021-924X Print   Jorunal Code : 0376600
  • Highly Efficient Isothermal DNA Amplification System Using Three Elements of 5'-DNA-RNA-3' Chimeric Primers, RNaseH and Strand-displacing DNA Polymerase.
    Mukai Hiroyuki,et al., Journal of biochemistry Vol.142 (2) p273-281 (Japan)
    ISSN : 0021-924X Print   Jorunal Code : 0376600

AgriBio

  • Antidiabetic activities of chalcones isolated from a Japanese Herb, Angelica keiskei.
    Enoki Tatsuji, et al., Journal of agricultural and food chemistry Vol.55 (15) p6013-6017 (United States)
    ISSN : 0021-8561 Print   Jorunal Code : 0374755

2006

MazF

  • Development of anti-HIV gene therapy strategy using novel endoribonuclease, MazF (II).
    Mineno Junichi(Reprint), et al. JOURNAL OF GENE MEDICINE Vol.8 (12) Page.1465 DEC 2006
    ISSN : 1099-498X_(print) 1521-2254_(electronic)
  • Development of anti-HIV gene therapy strategy using novel endoribonuclease, MazF (I)
    Chono Hideto(Reprint), et al. JOURNAL OF GENE MEDICINE Vol.8 (12) Page.1464-1465 DEC 2006
    ISSN : 1099-498X_(print) 1521-2254_(electronic)

miRNA

  • The expression profile of microRNAs in mouse embryos.
    Mineno Junichi, et al. Nucleic acids research Vol.34 (6) p1765-1771(England)
    ISSN : 1362-4962 Electronic   Jorunal Code : 0411011

Plants

  • Characterisation of BRR1, a brassinosteroid-responsive ring-finger gene from Arabidopsis.
    Umeda Kahoko(Reprint), et al. Plant and Cell Physiology Vol.47 (Suppl. S) Page.S184 2006
    ISSN : 0032-0781

AgriBio

  • Insulin-like activities of chalcone derivatives, xanthoangelol (XA) and 4-hydroxyderricin (41RD), from a Japanese herb, Angelica keiskei: Induction of adipocyte differentiation and enhancement of glucose uptake in adipocyte.
    Enoki Tatsuji(Reprint), et al. FASEB Journal Vol.20 (5, Part 2) Page.A1018 MAR 7 2006
    ISSN : 0892-6638
  • Tumor-growth inhibitory activity of the terpene compound isolated from Buna-shimeji mushroom
    Mizutani Shigetoshi(Reprint), et al. Nippon Shokuhin Kagaku Kogaku Kaishi Vol.53 (1) Page.55-61 2006
    ISSN : 1341-027X

2005

MazF

  • Insights into the mRNA cleavage mechanism by MazF, an mRNA interferase.
    Zhang Yonglong, et al. Journal of biological chemistry
    Vol.280 (5) p3143-3150 (United States)
    ISSN : 0021-9258 Print   Jorunal Code : 2985121R

2004

AgriBio

  • Isolation and characterization of a fucoidan-degrading marine bacterial strain and its fucoidanase.
    Sakai Takeshi(Reprint), et al. Marine Biotechnology (New York) Vol.6 (4) Page.335-346 July 2004
    ISSN : 1436-2228 _(ISSN print)

2003

AgriBio

  • Structures of oligosaccharides derived from Cladosiphon okamuranus fucoidan by digestion with marine bacterial enzymes.
    Sakai Takeshi(Reprint), et al. Marine Biotechnology (New York) Vol.5 (6) Page.536-544 November-December 2003
    ISSN : 1436-2228 _(ISSN print)
  • Isolation and characterization of a fucoidan-degrading marine bacterium.
    Sakai Takeshi(Reprint), et al. Marine Biotechnology (New York) Vol.5 (5) Page.409-416 September-October 2003
    ISSN : 1436-2228 _(ISSN print)
  • Purification of sulfated fucoglucuronomannan lyase from bacterial strain of Fucobacter marina and study of appropriate conditions for its enzyme digestion.
    Sakai Takeshi(Reprint), et al. Marine Biotechnology (New York) Vol.5 (4) Page.380-387 July-August 2003
    ISSN : 1436-2228 _(ISSN print)
  • Marine bacterial sulfated fucoglucuronomannan (SFGM) lyase digests brown algal SFGM into trisaccharides.
    Sakai Takeshi(Reprint), et al. Marine Biotechnology (New York) Vol.5 (1) Page.70-78 January-February 2003
    ISSN : 1436-2228 _(ISSN print)
  • Structures of oligosaccharides derived from Cladosiphon okamuranus fucoidan by digestion with marine bacterial enzymes. Sakai Takeshi, et al. Marine biotechnology (New York, N.Y.) Vol.5 (6) p536-544 (United States)
    ISSN : 1436-2228 Print   Jorunal Code : 100892712

Microarray

  • Development of the test method for detection of endocrine-disrupting activity using DNA microarrays.
    Kondo Akihiro(Reprint), et al. Book:Toxicogenomics Page.135-140

ICAN method (Japanese)

  • Evaluation of the simultaneous detection system for Chlamydia trachomatis/Neisseria gonorrhoeae DNA by the isothermal and chimeric primer-initiated amplification of nucleic acids (ICAN).
    Shimada Masamitsu, et al. Rinsho byori. The Japanese journal of clinical pathology Vol.51 (11) p1061-7 (Japan)
    ISSN : 0047-1860 Print   Jorunal Code : 2984781R

2002

AgriBio

  • A marine strain of Flavobacteriaceae utilizes brown seaweed fucoidan.
    Sakai Takeshi(Reprint), et al. Marine Biotechnology (New York) Vol.4 (4) Page.399-405 July-August, 2002
    ISSN : 1436-2228
  • Oligosaccharides of agar show strong anti-inflammatory activities: By inducing hemeoxygenase-I (HO-1); suppressing the expression of inducible nitrogen oxide synthase (iNOS) and TNF-alpha.
    Sagawa Hiroaki(Reprint), et al. FASEB Journal Vol.16 (4) Page.A223 March 20, 2002
    ISSN : 0892-6638

ICAN method (Japanese)

  • Development of the detection system for Mycobacterium tuberculosis DNA by using the isothermal DNA amplification method ICAN.
    Shimada Masamitsu, et al. Rinsho byori. The Japanese journal of clinical pathology Vol.50 (5) p528-532 (Japan)
    ISSN : 0047-1860 Print   Jorunal Code : 2984781R

2001

DNA microarray

  • Application of fluorescently labeled poly(dU) for gene expression profiling on cDNA microarrays,
    Meiyanto E, Mineno J, Ishida N, Takeya T., BioTechniques, (2011) 31: 406-413.

RetroNectin

  • Removal of inhibitory substances with recombinant fibronectin-CH-296 plates enhances the retroviral transduction efficiency of CD34+CD38- bone marrow cells.
    Chono Hideto, et al. Journal of Biochemistry (Tokyo) Vol.130 (3) Page.331-334 Sep., 2001
    ISSN : 0021-924X

ICAN method (Japanese)

  • Application of genetic diagnosis for colorectal cancer Shimada M,
    Rinsho byori. The Japanese journal of clinical pathology Vol.49 (12) p1237-1241 (Japan)
    ISSN : 0047-1860 Print   Jorunal Code : 2984781R

2000

PCR

  • The magnetic immuno polymerase chain reaction assay for detection of Salmonella from food and fecal samples,
    Ueda S, Umesako S, Mineno J, and Kuwabara Y., Biocontrol Science, (2000) 5: 25-32.

Fungous vaccine

  • Immunization with the Candida albicans membrane fraction and in combination with fluconazole protects against systemic fungal infections.
    Mizutani Shigetoshi(Reprint), et al. Antimicrobial Agents and Chemotherapy Vol.44 (2) Page.243-247 Feb., 2000
    ISSN : 0066-4804

Proteomics (Japanese)

  • Deblocking aminopeptidase from Pyrococcus furiosus and its application for proteomics.
    Tsunasawa S, Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme Vol.45 (2) p186-192 (JAPAN)
    ISSN : 0039-9450 Print   Jorunal Code : 0413762

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